Karyopharm Therapeutics Inc. has been awarded a grant from the National Multiple Sclerosis (MS) Society through its affiliate, Fast Forward, to support research on the potential of SINE compounds in inflammatory disease, including MS.   SINE compounds inhibit Exportin-1 (XPO1 or CRM1), which mediates the export of mammalian cargo proteins. In MS, toxic factors accumulate in the brain and spinal cord that may attack or destroy the myelin coating on a neuron’s axon leading to neurodegenerati...